Experimental models of autism spectrum disorders on the example of the use of brain organelles

Introduction ASD are heterogeneous pathological conditions characterized by difficulties in establishing social contacts and the manifestation of repetitive behavior. An atypical trajectory brain maturation, impaired neurogenesis, synaptogenesis, an imbalance excitatory inhibitory systems CNS form morphofunctional basis ASD. Objectives To understand functioning this complexly organized system time space, a three-dimensional model is needed. The closest vitro human from early embryonic stages to aging organoids. Human organoids self-organizing cell aggregates derived pluripotent stem cells (hiPSCs) Methods Organelles generalize gliogenesis, migration differentiation, gyrification cerebral cortex, reflect connections regions. Results use telencephalon organelles RAS revealed deficit neuronal migration, acceleration disruption cycle synchronization, aberrant proliferation, abundant temporary deviations development increased branching neurons, unbalanced differentiation high activity ion channels consequence violation FOXG1 activity. regions.The . Conclusions hiPSCs can provide insight into cellular mechanisms underlying as neuropsychiatric disorder, providing access platforms for drug screening individualized patient therapy. Disclosure Interest None Declared